The sanctuary, made of sandstone, has a Greek cross plan and an octagonal dome supported inside by four pillars. Also noteworthy are the portals of the building, created by Rocco himself, Giuliano da Verona, Bernardino da Siena, and Lorenzo da Carrara. The interior has a square plan with four chapels at the corners, plus the main chapel that holds the miraculous painting. Among the notable works are the Deposition from the Cross by Arrigo Fiammingo, a Resurrection by Nicolò Pomarancio, the Coronation of Mary depicted on the dome by Mattia Batini, and other important sacred images, most notably the miraculous one representing the Madonna and Child, dating back to the 14th century. In addition to the paintings, the stone high altar and the terracotta statues located in the organ's niches, crafted by Bevignate da Perugia and Arrigo Fiammingo, also stand out.