The structure was totally built with sandstone: the façade was executed by Domenico Bertini, and the squat tower was rebuilt in 1851, after the collapse of the previous one in 1531. The sanctuary has a Latin-cross design, with a vast single nave; on the left wall you can admire paintings by the Perugia school dating back to the 1500s.
A wooden crucifix is located in the right arm of the transept, within a small chapel of pietra serena stone, frescoed by Tommaso Papacello. The two tondi with figures of the prophets Micah and Isaiah, located on the pillars of the triumphal arch, were executed by Domenico Alfani.
In the apse is the painting depicting the Epiphany, executed by Alfani after cartoons by Rosso Fiorentino. The chapel in the left transept, also in pietra serena, houses a picture of the Virgin with the Child, dating back to the end of the 16th century.  The painting by G.B. Caporali depicting the Coronation of the Virgin is located above the second altar on the left.