Rufion was probably in the emperor's service during the Alexandrian civil war (48-47 BC); at the end of the conflict, Caesar gave Rufion command of the three legions he left in Alexandria as support for Queen Cleopatra, his lover. Later the legions became four, and in 43 B.C. Aulus Allienus was put in command of them.

The villa shows a continuity of use up to the 4th century AD with substantial restoration in the Flavian age. The proximity to the Via Flaminia and the material so far returned by archaeological investigations suggest a structure consisting of several pavilions, of which the main and most important may have had its entrance right near the consular road. In fact, the excavation has brought to light 18 rooms, two of which belonged to a thermal facility, decorated with mosaics that are only partially preserved; the decorative wall decorations are also rich, of which frustules of the marble covering and frescoes remain.

The valuable artefacts from the Roman villa at Rufione are collected in the Antiquarium Archaeological Museum near Montecchio and were of fundamental importance for studying daily life inside the villa: fragments of polychrome frescoes and stuccoes, glass balsamware, nails and iron artefacts, coins, as well as terracotta and amphorae furnishings.